The synthesis, characterization and cytotoxicity studies of two novel platinum(IV) complexes, trans-PtCl₄(dma)(PPh₃), 1, and trans-PtCl₄(ipa)(PPh₃), 2, where dma is dimethylamine and ipa is isopropylamine, have been carried out. Both complexes contain aliphatic amines trans to phosphane ligands as a good alternative to take advantage of the phosphane group lipophilicity and the stability of platinum(IV) to obtain more effective drugs. Moreover, the complexes are stable in solution and such stability allowed their antitumoral action and DNA interaction to be checked and proved.