A rapid and clean synthetic approach to cyclic peptides via micro-flow peptide chain elongation and photochemical cyclization: synthesis of a cyclic RGD peptide†,10.1039/C6OB02391F

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A rapid and clean synthetic approach to cyclic peptides via micro-flow peptide chain elongation and photochemical cyclization: synthesis of a cyclic RGD peptide†

Yuto Mifune,Hiroyuki Nakamura,Shinichiro Fuse

Organic & Biomolecular Chemistry Pub Date : 11/16/2016 00:00:00 , DOI:10.1039/C6OB02391F

Abstract

A cyclic RGD peptide was efficiently synthesized based on micro-flow, triphosgene-mediated peptide chain elongation and micro-flow photochemical macrolactamization. Our approach enabled a rapid (amidation for peptide chain elongation <5 s, macrolactamization <5 min) and clean (only one column chromatographic separation) synthesis of a cyclic peptide.