Because of their abundance and low cost, organo chlorides are the most desirable substrates from the industrial point of view in Suzuki–Miyaura cross-coupling reactions. However, catalytic application of Pd nanoparticles (NPs) for Suzuki coupling of aryl chlorides is still a challenge. Here, we design a novel catalyst by combining Pd NPs with Co3[Co(CN)6]2 nanocrystals for Suzuki–Miyaura coupling of aryl chlorides. This nanocatalyst demonstrated good activity (yield 86.2% at 80 °C), high TOF, great stability, easy separation, excellent reusability (initial rates were not reduced after five cycles) and low cost in Suzuki reactions.
![Graphical abstract: Pd–Co3[Co(CN)6]2 hybrid nanoparticles: preparation, characterization, and challenge for the Suzuki–Miyaura coupling of aryl chlorides under mild conditions](http://hg.y866.cn/compound/lib/scimg/usr/1/C5DT03631C.jpg)
