Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser†
Jordan Atchison,Sukanta Kamila,Conor McEwan,Heather Nesbitt,James Davis,Colin Fowley,Bridgeen Callan,Anthony P. McHale,John F. Callan
Abstract
A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.
