An investigation into the occurrence of volatile organic compounds (VOCs) in the surface water of Poyang Lake was conducted. The determination of 54 different kinds of VOCs was performed with a purge and trap-gas chromatography-mass spectrometry method at 28 sampling points. Twenty-two types of VOCs were detected; methylene chloride had the highest mean concentration of 708.19 ng L−1, followed by 1,2-dichloroethane and chloroform, with mean concentrations of 376.78 and 187.26 ng L−1, respectively. The distribution of VOCs in the areas of Poyang Lake from low to high was as follows: west and south < east and central; the highest ∑VOC concentration occurred at the sample site of Zhangsihe. The health risks of VOCs in Poyang Lake were also determined by calculating the cancer and non-cancer risk from the two exposure routes of ingestion and dermal adsorption. The results showed that VOCs have no carcinogenicity risk, while only methylene chloride has a certain carcinogenic risk to the human body.
