Prediction of the stability of modified RNA duplexes based on deformability analysis: oligoribonucleotide derivatives modified with 2′-O-cyanoethyl-5-propynyl-2-thiouridine as a promising component†
Yoshiaki Masaki,Ryuta Miyasaka,Kunihiro Hirai,Hirosuke Tsunoda,Akihiro Ohkubo,Kohji Seio,Mitsuo Sekine
Abstract
We describe a method to predict the stability of a modified RNA duplex. Ten unique modified RNA duplexes showed a linear relationship between the calculated and experimentally determined duplex stabilities.
