Rational engineering of Candida antarctica lipase B for selective monoacylation of diols†
Anders Hamberg,Steffen Maurer,Karl Hult
Chemical Communications Pub Date : 08/22/2012 00:00:00 , DOI:10.1039/C2CC34684B
Abstract
The enzyme Candida antarctica lipase B was subjected to site directed mutagenesis suggested by molecular modelling. The selectivity for the enzyme increased towards a range of diols over their corresponding monoesters as an effect of the mutations.
