One-pot metal-free synthesis of highly substituted pyrroles from 2-acetyl-3-methylene-1,4-dicarbonyl compounds and primary amines via TBHP and activated carbon oxidative aromatization of dihydropyrrole†,10.1039/C3RA47782G

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

One-pot metal-free synthesis of highly substituted pyrroles from 2-acetyl-3-methylene-1,4-dicarbonyl compounds and primary amines via TBHP and activated carbon oxidative aromatization of dihydropyrrole†

Wei Yang,Yu Zhou,Haifeng Sun,Lei Zhang,Fei Zhao,Hong Liu

RSC Advances Pub Date : 03/13/2014 00:00:00 , DOI:10.1039/C3RA47782G

Abstract

A metal-free one-pot cascade process for the synthesis of 1,2,3,4-tetrasubstituted pyrroles via a tandem enamine, aza-Michael addition and TBHP, activated carbon oxidative aromatization is reported. This strategy features the formation of two C–N bonds in moderate to excellent yields and a broad substrate tolerance.