This review, with 290 references, presents the fascinating area of iodinated natural products over the past hundred years for the first time. It covers literature published from 1896 to 2014 and refers to compounds isolated from both biogenic and abiotic sources. In total, 182 naturally-occurring organoiodine compounds are recorded. The emphasis is on the compounds together with the relevant biological activities, sources, collection places, countries of origin, biosynthetic studies, and first total syntheses.