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One-pot tandem enantioselective hydrogenation–hydroformylation synthesis of cyclic α-amino acids
Euneace Teoh,Eva M. Campi,W. Roy Jackson,Andrea J. Robinson
New Journal of Chemistry Pub Date : 01/03/2003 00:00:00 , DOI:10.1039/B209087M
Abstract

Five- and six-membered cyclic amino acids can be prepared in good yield with high ee (>95%) via tandem rhodium-DuPHOS catalysed asymmetric hydrogenation followed by a rhodium-catalysed hydroformylation–cyclisation sequence in a single pot. The synthesis can be achieved using Rh-DuPHOS as the sole catalyst.

Graphical abstract: One-pot tandem enantioselective hydrogenation–hydroformylation synthesis of cyclic α-amino acids
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