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A practical and chemoselective Mo-catalysed sulfoxide reduction protocol using a 3-mercaptopropyl-functionalized silica gel (MPS)†
Nuria García,Manuel A. Fernández-Rodríguez,Patricia García-García,María R. Pedrosa,Francisco J. Arnáiz,Roberto Sanz
RSC Advances Pub Date : 03/07/2016 00:00:00 , DOI:10.1039/C6RA03106D
Abstract

A convenient sulfoxide deoxygenation procedure using a mercaptopropyl-functionalized silica gel as the reducing agent is described. This new protocol based on a heterogeneous reagent displays broad scope and tolerance to reducible functional groups and, from an experimental point of view, enhances previous methods by simplifying the isolation of the sulfide to a simple filtration.

Graphical abstract: A practical and chemoselective Mo-catalysed sulfoxide reduction protocol using a 3-mercaptopropyl-functionalized silica gel (MPS)
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