A series of coumarin-annulated azepines were synthesized via acid-catalyzed condensation of 3-amino-4-hydroxycoumarin with two equivalents of substituted acetophenones in toluene with moderate to good yields. A plausible mechanism for this pseudo three-component reaction was proposed.
![Graphical abstract: Pseudo three-component approach to coumarin-annulated azepines: synthesis of coumarin[3,4-b]azepines](http://hg.y866.cn/compound/lib/scimg/usr/1/C7RA09289J.jpg)
