A novel magnetic nanoparticle CoFe2O4 supported Mo ([CoFe2O4@SiO2-PrNH2-Mo(acac)2]) was prepared and found to be a highly active and efficient catalyst for a one-pot synthesis of polysubstituted pyrroles via four-component reaction of aldehydes, amines, 1,3-dicarbonyl compounds and nitromethane. The easy recovery of the catalyst and reusability, broad substrate scopes, short reaction time, high yields of products and solvent-free conditions make this protocol practical, environmentally friendly and economically attractive.
