Ni(i)–Ni(iii) cycle in Buchwald–Hartwig amination of aryl bromide mediated by NHC-ligated Ni(i) complexes†,10.1039/C8CY02427H

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Ni(i)–Ni(iii) cycle in Buchwald–Hartwig amination of aryl bromide mediated by NHC-ligated Ni(i) complexes†

Takahiro Inatomi,Yukino Fukahori,Yuji Yamada,Ryuta Ishikawa,Shinji Kanegawa,Yuji Koga,Kouki Matsubara

Catalysis Science & Technology Pub Date : 02/13/2019 00:00:00 , DOI:10.1039/C8CY02427H

Abstract

Intermediate amide complexes of NHC-ligated monovalent nickel in Buchwald–Hartwig amination of aryl halides were isolated and structurally characterized. The amide complexes reacted with aryl bromide to form a cross-coupling product. Low-temperature observation of the oxidative addition product of the Ni(I) amide complex with aryl bromide indicated the presence of a Ni(III) intermediate. The results showed that a well-defined mononuclear NHC–Ni(I) complex can act as a key intermediate in homogeneous catalysis.