Nickel(0)-catalyzed [2 + 2 + 2] cycloaddition of diynes and 3,4-pyridynes: novel synthesis of isoquinoline derivatives†
Toshihiko Iwayama,Yoshihiro Sato
Chemical Communications Pub Date : 08/03/2009 00:00:00 , DOI:10.1039/B912022J
Abstract
A transition metal-catalyzed [2 + 2 + 2] cycloaddition between α,ω-diynes and 3,4-pyridynes has been realized for the first time, producing isoquinolines in good yields by using a nickel(0) catalyst.
![Graphical abstract: Nickel(0)-catalyzed [2 + 2 + 2] cycloaddition of diynes and 3,4-pyridynes: novel synthesis of isoquinoline derivatives](http://hg.y866.cn/compound/lib/scimg/usr/1/B912022J.jpg)
