Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin†,10.1039/C5CC10446G

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Potent inhibition of cyclic diadenylate monophosphate cyclase by the antiparasitic drug, suramin†

Chemical Communications Pub Date : 01/22/2016 00:00:00 , DOI:10.1039/C5CC10446G

Abstract

C-di-AMP synthases are essential in several bacteria, including human pathogens; hence these enzymes are potential antibiotic targets. However, there is a dearth of small molecule inhibitors of c-di-AMP metabolism enzymes. Screening of 2000 known drugs against DisA has led to the identification of suramin, an antiparasitic drug as potent inhibitor of c-di-AMP synthase.