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Palladium catalyzed chemo- and site-selective C–H acetoxylation and hydroxylation of oxobenzoxazine derivatives†
Manickam Bakthadoss,Polu Vijay Kumar,Ravan Kumar,Vishal Agarwal
Organic & Biomolecular Chemistry Pub Date : 04/12/2019 00:00:00 , DOI:10.1039/C9OB00642G
Abstract

An efficient protocol for the introduction of acetoxy and hydroxy functionalities on unactivated aryl sp2 carbons of oxobenzoxazine derivatives via an ortho-C–H activation reaction using a palladium catalyst has been developed for the first time. Interestingly, this intermolecular C–H functionalization reaction takes place in a facile and simple manner with high chemo- and site selectivity.

Graphical abstract: Palladium catalyzed chemo- and site-selective C–H acetoxylation and hydroxylation of oxobenzoxazine derivatives
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