Palladium(0)-catalyzed direct C–H hetero-arylation of 2-arylimidazo [1,2-a]pyridines with (E)-1-(5-bromothiophen-2-yl)-3-arylprop-2-en-1-ones and their anticancer activity†,10.1039/C5RA15078G

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Palladium(0)-catalyzed direct C–H hetero-arylation of 2-arylimidazo [1,2-a]pyridines with (E)-1-(5-bromothiophen-2-yl)-3-arylprop-2-en-1-ones and their anticancer activity†

Mari Vellakkaran,Bejjanki Naveen Kumar,Y. Poornachandra,C. Ganesh Kumar

RSC Advances Pub Date : 09/15/2015 00:00:00 , DOI:10.1039/C5RA15078G

Abstract

An efficient palladium(0)-catalyzed direct hetero-arylation of imidazo[1,2-a]pyridines at the C-3 position of the imidazole ring has been described. All the synthesized compounds 3a–3r were evaluated for their anticancer activity against a panel of four human cancer cell lines and among all the compounds, 3d, 3j, 3k, 3p and 3r showed promising activity at <10 μM.