960化工网
Reactive barium-promoted Reformatsky-type reaction of α-chloroketones with aldehydes
Akira Yanagisawa,Hiroshi Takahashi,Takayoshi Arai
Chemical Communications Pub Date : 02/03/2004 00:00:00 , DOI:10.1039/B314752P
Abstract

A Reformatsky-type aldol reaction of α-chloroketones with aldehydes has been achieved using reactive barium as a low-valent metal in THF; this one-pot process is more effective for obtaining the desired β-hydroxy ketones in high yields than the stepwise process in which barium enolates are prepared prior to the reaction with aldehydes.

Graphical abstract: Reactive barium-promoted Reformatsky-type reaction of α-chloroketones with aldehydes
平台客服
平台客服
平台在线客服