We have designed and synthesized two novel vanadium coordination compounds using 1H-benzimidazole-2-carboxylic acid and 5-aminopyridine-2-carboxylic acid. These two materials have a mononuclear structure with crystallization water molecules in the network. Both compounds exhibit intense photoluminescence emission at room temperature in the solid state and show in vivo antidiabetic activity together with low in vitro cell toxicities. Luminescence theoretical studies have been performed.