C–C bond formation using transition metal catalyzed Sonogashira coupling reaction is an indispensable tool in synthetic organic chemistry. Initially Pd complexes were used as catalysts; however advances in catalyst design fuelled the development of Cu catalysts, which are cheaper and more environmentally benign than the Pd complexes. This is the first review reported so far dealing exclusively with Cu-catalyzed Sonogashira coupling reactions. This review illustrates the current strategies and potential of Cu-catalyzed Sonogashira coupling reactions.