Sassafras oil, carrot bits and microwaves: green lessons learned from the formal total synthesis of (−)-talampanel†,10.1039/C5RA19483K

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Sassafras oil, carrot bits and microwaves: green lessons learned from the formal total synthesis of (−)-talampanel†

Alvaro Takeo Omori,Camila de Souza de Oliveira,Kleber Tellini Andrade,Marina Gonçalves Capeletto

RSC Advances Pub Date : 11/26/2015 00:00:00 , DOI:10.1039/C5RA19483K

Abstract

A formal total synthesis of (−)-talampanel (1), a 2,3-benzodiazepine is described. This work was undertaken to utilize greener reaction conditions. Safrole (a renewable source) was converted to (1) in eight steps, including an enantioselective bioreduction using carrots as the key step. Microwave irradiation was also used to perform three reaction steps.