O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma†,10.1039/C7CC00213K

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

O2-(6-Oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolates: a new class of nitric oxide donors activatable by GSH/GSTπ with both anti-proliferative and anti-metastatic activities against melanoma†

Chengfeng Bai,Rongfang Xue,Jianbing Wu,Tian Lv,Xiaojun Luo,Yun Huang,Yan Gong,Honghua Zhang,Yihua Zhang,Zhangjian Huang

Chemical Communications Pub Date : 04/12/2017 00:00:00 , DOI:10.1039/C7CC00213K

Abstract

The new nitric oxide (NO) donor O²-(6-oxocyclohex-1-en-1-yl)methyl diazen-1-ium-1,2-diolate 3c could simultaneously liberate NO as well as an active 3-glutathionyl-2-exomethylene-cyclohexanone 2 in the presence of GSH/GSTπ; exhibit potent antiproliferative activity; repress migration, invasion, and lateral migration of metastatic B16–BL6 cells; and significantly decrease hetero-adhesion of B16–BL6 cells to human umbilical vein endothelial cells.