In this study, a serial microbubble imaging technology (sMBI) is proposed as a new high-throughput technology (HTE) detection method for rapid screening of hydrogen-evolution catalytic materials. The mechanism for the screening is based on capturing the variation in the growth of microbubbles in a system involving thousands of catalysts to evaluate numerous reactions. As an example of the process, three catalysts with high catalytic activity were rapidly selected from 1260 candidates.