Occurrence of spontaneous resolution of ketoprofen with a racemic crystal structure by simple crystallization under nonequilibrium preferential enrichment conditions†‡
Rajesh G. Gonnade,Sekai Iwama,Ryusuke Sugiwake,Kochunnoonny Manoj,Hiroki Takahashi,Hirohito Tsue,Rui Tamura
Chemical Communications Pub Date : 01/27/2012 00:00:00 , DOI:10.1039/C2CC18132K
Abstract
Nearly racemic ketoprofen, which satisfies the requirements for the occurrence of preferential enrichment, was spontaneously resolved into the two enantiomers by simple crystallization under nonequilibrium conditions using high concentrations.
