Silica gel promoted environment-friendly synthesis of α-amino amidines and regioselective transformation of α-amino amidines into amidino substituted indazoles†,10.1039/C5RA02491A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Silica gel promoted environment-friendly synthesis of α-amino amidines and regioselective transformation of α-amino amidines into amidino substituted indazoles†

A. Sagar,Venkata Nagarjuna Babu,Duddu. S. Sharada

RSC Advances Pub Date : 03/23/2015 00:00:00 , DOI:10.1039/C5RA02491A

Abstract

Environment-friendly three-component Ugi-type strategy (U-3CR) for the synthesis of a wide variety of α-amino amidines has been developed by using silica gel as promoter, and a novel access to amidino substituted indazoles in a regioselective manner is presented via iron(III) catalyzed post Ugi cyclization strategy. This method allows an easy construction of amidino substituted indazoles in good yields with broad substrate scope starting from readily available starting materials.