A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles†,10.1039/C1CC11363A

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A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles†

Xufeng Lin,Zhenjun Mao,Xixiang Dai,Ping Lu,Yanguang Wang

Chemical Communications Pub Date : 05/12/2011 00:00:00 , DOI:10.1039/C1CC11363A

Abstract

Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benz[g]indole.