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One-pot synthesis of 2,3-substituted benzo[b]thiophenes via Cu(i) catalysed intramolecular cyclisation from dithioesters†
Nagarakere. C. Sandhya,Kebbahalli. N. Nandeesh,Kanchugarakoppal. S. Rangappa,Sannaiah. Ananda
RSC Advances Pub Date : 03/27/2015 00:00:00 , DOI:10.1039/C5RA02114F
Abstract

Efficient synthesis of benzo[b]thiophenes from o-halophenyl acetonitrile has been achieved. This novel one-pot procedure involves CuI and pivalic acid catalyzed C–S bond formation using dithioesters followed by a heterocyclization reaction. This efficient protocol has the advantages of one-pot synthesis, short reaction time, good yields (62–78%) and operational simplicity.

Graphical abstract: One-pot synthesis of 2,3-substituted benzo[b]thiophenes via Cu(i) catalysed intramolecular cyclisation from dithioesters
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