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Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: a new route to isoquinolones†
Mallu Chenna Reddy,Rajendran Manikandan,Masilamani Jeganmohan
Chemical Communications Pub Date : 05/16/2013 00:00:00 , DOI:10.1039/C3CC42683A
Abstract

The oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes in the presence of a catalytic amount of [{RuCl2(p-cymene)}2], Cu(OAc)2·H2O and KPF6 in acetic acid under air gave isoquinolones in good to excellent yields.

Graphical abstract: Ruthenium-catalyzed aerobic oxidative cyclization of aromatic and heteroaromatic nitriles with alkynes: a new route to isoquinolones
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