Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)–H bonds directed by a sulfur atom†
Longhui Gao,Serge Perato,Sébastien Garcia-Argote,Céline Taglang,Luis Miguel Martínez-Prieto,Céline Chollet,David-Alexandre Buisson,Vincent Dauvois,Philippe Lesot,Bruno Chaudret,Bernard Rousseau,Sophie Feuillastre,Grégory Pieters
Abstract
We present here the first example of C(sp3)–H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a hydrogen isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules.
