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Polycyclic alkaloidsvia transannular Mannich reactions†
Paulo Vital,Masood Hosseini,M. Sundaram Shanmugham,Charlotte H. Gotfredsen,Pernille Harris,David Tanner
Chemical Communications Pub Date : 02/19/2009 00:00:00 , DOI:10.1039/B822955D
Abstract

The tricyclic compound 13, representing the framework of the cylindricine 4 and lepadiformine 5alkaloids, was prepared in a single operation via the first example of a transannular Mannich reaction involving a macrocyclic diketoamine 12.

Graphical abstract: Polycyclic alkaloidsvia transannular Mannich reactions
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