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Organocatalytic kinetic resolution via intramolecular aldol reactions: Enantioselective synthesis of both enantiomers of chiral cyclohexenones†
Liujuan Chen,Sanzhong Luo,Jiuyuan Li,Xin Li,Jin-Pei Cheng
Organic & Biomolecular Chemistry Pub Date : 04/01/2010 00:00:00 , DOI:10.1039/B927343C
Abstract

Kinetic resolution of 6-aryl-2,6-hexanediones was achieved with chiral secondary amine catalyzed intramolecular aldolization. The current kinetic resolution protocol enables the synthesis of both enantiomers of cyclohexenones with moderate to good enantioselectivity.

Graphical abstract: Organocatalytic kinetic resolution via intramolecular aldol reactions: Enantioselective synthesis of both enantiomers of chiral cyclohexenones
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