Rapid, catalyst free, solid phase modification of DNA by strain promoted cyclooctyne–nitrile oxide click chemistry is reported; the reaction is characterised by mild conditions, occurring in an aqueous environment under atmospheric conditions at room temperature and is complete in 10 minutes.
![Graphical abstract: Solid phase strain promoted “click” modification of DNAvia[3+2]-nitrile oxide–cyclooctyne cycloadditions](http://hg.y866.cn/compound/lib/scimg/usr/1/C0CC03985C.jpg)
