960化工网
Portable resistive pulse-activated lens-free cell imaging system
Jinhong Guo,Xiwei Huang,Dongyuan Shi,Hao Yu,Ye Ai,Chang Ming Li,Yuejun Kang
RSC Advances Pub Date : 10/15/2014 00:00:00 , DOI:10.1039/C4RA10481A
Abstract

We demonstrate a portable lens-free cell imaging system activated by resistive pulses that are induced by biological cells in a microfluidic channel. This imaging on-chip flow cytometer integrates CMOS with microfluidics as a standalone on-chip analytical device. The preliminary version of this system is able to provide dual-parametric study (light contrast image and modulated electrical pulse) for each biological cell. Red blood cells and a tumor cell line (HepG2) are used to demonstrate the performance of this chip for flow analysis of biological samples.

Graphical abstract: Portable resistive pulse-activated lens-free cell imaging system
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