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Palladium-catalyzed synthesis of fluoreones from bis(2-bromophenyl)methanols†
Qian Gao,Senmiao Xu
Organic & Biomolecular Chemistry Pub Date : 12/12/2017 00:00:00 , DOI:10.1039/C7OB02895D
Abstract

A palladium-catalyzed synthesis method of fluorenones has been developed. A variety of bis(2-bromophenyl)methanols could undergo the reaction smoothly in the presence of Pd(OAc)2, affording a series of fluorenones in moderate to good yields (two steps). Mechanistic studies reveal that the reaction might be triggered by oxidation of alcohol followed by intramolecular reductive coupling.

Graphical abstract: Palladium-catalyzed synthesis of fluoreones from bis(2-bromophenyl)methanols
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