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Palladium-catalyzed desulfitative C-arylation of a benzo[d]oxazole C–H bond with arenesulfonyl chlorides†
Manli Zhang,Shouhui Zhang,Miaochang Liu,Jiang Cheng
Chemical Communications Pub Date : 09/23/2011 00:00:00 , DOI:10.1039/C1CC14718H
Abstract

A palladium-catalyzed direct desulfitative C-arylation of a benzo[d]oxazole C–H bond with arene sulfonyl chlorides is described. The procedure tolerates halo, cyano, nitro, trifluoromethyl, acetyl and acetylamino groups on the phenyl ring of sulfonyl chlorides, providing the arylation products in moderate to good yields. It represents a practical and attractive alternative for the synthesis of 2-aryl benzoxazoles.

Graphical abstract: Palladium-catalyzed desulfitative C-arylation of a benzo[d]oxazole C–H bond with arene sulfonyl chlorides
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