Synthesis and biological evaluation of potential new inhibitors of the bacterial transferase MraY with a β-ketophosphonate structure†,10.1039/C1OB06124K

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis and biological evaluation of potential new inhibitors of the bacterial transferase MraY with a β-ketophosphonate structure†

Nicolas Auberger,Rok Frlan,Bayan Al-Dabbagh,Ahmed Bouhss,Muriel Crouvoisier,Christine Gravier-Pelletier,Yves Le Merrer

Organic & Biomolecular Chemistry Pub Date : 09/14/2011 00:00:00 , DOI:10.1039/C1OB06124K

Abstract

Stable analogs of bacterial transferase MraY substrate or product with a pyrophosphate surrogate in their structure are described. β-ketophosphonates were designed as pyrophosphate bioisosteres and were investigated as UDP-GlcNAc mimics. The developed strategy allows introduction of structural diversity at a late stage of the synthesis. The biological activity of the synthesized compounds was evaluated on the MraY enzyme.