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Synthesis of 3-arylindole derivatives from nitroalkane precursors†
Chia-Yu Huang,Chun-Wei Kuo,Ashok Konala,Tang-Hao Yang,Lyu Lin,Yu-Wen Chen,Veerababurao Kavala,Ching-Fa Yao
RSC Advances Pub Date : 10/03/2016 00:00:00 , DOI:10.1039/C6RA21144E
Abstract

3-Arylindole derivatives were synthesized by Cu(I) catalysed intramolecular Ullmann coupling of 2-bromoarylaminoalkanes. 2-Bromoarylaminoalkanes were synthesized from 2-bromoarylnitroalkanes, which in turn prepared through AlCl3-mediated Friedel–Crafts alkylation of bromo-substituted β-nitrostyrenes and arenes.

Graphical abstract: Synthesis of 3-arylindole derivatives from nitroalkane precursors
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