Synthesis of a novel C2-aryl substituted 1,2-unsaturated pyrrolobenzodiazepine
Gyoung-Dong Kang,Philip W. Howard,David E. Thurston
Chemical Communications Pub Date : 06/11/2003 00:00:00 , DOI:10.1039/B303274D
Abstract
A novel C2-aryl 1,2-unsaturated PBD (14) has been prepared via an enol triflate intermediate (8). The regiochemistry of triflation is dependent upon the point at which the reaction is performed during the synthetic route.
