Synthesis of bis-exocyclic conjugated diene containing 1,2,3,4-tetrahydroquinoline derivatives via palladium-catalyzed intramolecular Heck cyclization†
Munmun Ghosh,Shubhendu Dhara,Yasin Nuree,Jayanta K. Ray
RSC Advances Pub Date : 09/08/2014 00:00:00 , DOI:10.1039/C4RA05900J
Abstract

An efficient method has been developed for the synthesis of bis-exocyclic conjugated diene containing 1,2,3,4-tetrahydroquinoline derivatives via palladium-catalyzed intramolecular Heck cyclization of (2-bromo-allyl)-(2-phenylethynyl-phenyl)-amines. The reaction followed 6-exo-dig cyclization to yield the desired products in moderate to good yields.

Graphical abstract: Synthesis of bis-exocyclic conjugated diene containing 1,2,3,4-tetrahydroquinoline derivatives via palladium-catalyzed intramolecular Heck cyclization