Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi†,10.1039/C9OB00807A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi†

Akiho Kaneko,Yohei Morishita,Kento Tsukada,Tohru Taniguchi,Teigo Asai

Organic & Biomolecular Chemistry Pub Date : 05/01/2019 00:00:00 , DOI:10.1039/C9OB00807A

Abstract

Polyketide synthase (PKS) gene-guided genome mining in a cricket-associated fungus, Penicillium soppi, revealed a cryptic biosynthetic gene cluster that contained a highly reducing PKS (HR-PKS), a type III PKS, and a P450 gene. Heterologous expression of the cluster in Aspergillus oryzae led to the isolation of novel alkylresorcinols with a unique Z,E,Z-triene motif. This study displays an unusual biosynthetic mechanism of an HR-PKS and a new releasing mechanism via a type III PKS in fungi.