This review presents the advances in the use of 6-aminouracil as a starting material in the synthesis of various heterocyclic structures such as pyrido-, pyrrolo-, and pyrimido-pyrimidines, fused spirooxindole derivatives, etc. There is a wide range of multicomponent reactions that include 6-aminouracil in the synthesis of various organic compounds. This review aims at showing representative examples of these multicomponent reactions in recent years.