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Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers†
Kaori Tsukakoshi,Yuri Ikuta,Koichi Abe,Wataru Yoshida,Keisuke Iida,Yue Ma,Kazuo Nagasawa,Koji Sode,Kazunori Ikebukuro
Chemical Communications Pub Date : 09/30/2016 00:00:00 , DOI:10.1039/C6CC07552E
Abstract

We report that a G-quadruplex-specific compound induced structural changes in G-quadruplex-forming DNA aptamers and stabilized the folded structures, making them suitable for targeted proteins and enhancing their binding properties.

Graphical abstract: Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers
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