Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4′-pyridines] by a reaction of oxindoles with 1,2-diaza-1,3-dienes†,10.1039/C4OB01959H

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Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4′-pyridines] by a reaction of oxindoles with 1,2-diaza-1,3-dienes†

Orazio A. Attanasi,Linda A. Campisi,Lucia De Crescentini,Gianfranco Favi,Fabio Mantellini

Organic & Biomolecular Chemistry Pub Date : 10/14/2014 00:00:00 , DOI:10.1039/C4OB01959H

Abstract

A simple reaction of some oxindole derivatives with 1,2-diaza-1,3-dienes to produce 2-oxo-spiro[indole-3,4′-pyridines] in good yields is described here. This transformation represents a practical two steps approach to new and biologically interesting 2-oxo-spiro[indole-3,4′-pyridine] scaffolds using a double Michael addition/cyclization sequence.