Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells†,10.1039/D0CC07821B

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells†

Li-Song Zhang,Hong-Lei Xu,Ying Xia,Jian-Peng Bi,Chuan-Zeng Zhang,Zhen Xi,Lu-Yuan Li,Zhi-Song Zhang

Chemical Communications Pub Date : 12/15/2020 00:00:00 , DOI:10.1039/D0CC07821B

Abstract

Caspase-3/8 are key members of the cysteine–aspartyl protease family with pivotal roles in apoptosis. We have designed and synthesized self-assembling probes, Nap-GFFpYDEVD-AFC and Nap-GFFpYIETD-AFC, with fluorescence ‘turn-on’ properties for real-time monitoring of Caspase-3/8 activity in living cells.