A three-component approach to isoxazolines and isoxazoles under metal-free conditions†,10.1039/C9OB01909J

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

A three-component approach to isoxazolines and isoxazoles under metal-free conditions†

Dahan Wang,Feng Zhang,Fuhong Xiao,Guo-Jun Deng

Organic & Biomolecular Chemistry Pub Date : 10/02/2019 00:00:00 , DOI:10.1039/C9OB01909J

Abstract

A 1,3-dipolar cycloaddition of 2-methylquinoline, tert-butyl nitrite (TBN) and alkynes or alkenes for the synthesis of biheteroaryls containing both isoxazoline/isoxazole and quinoline motifs has been developed. In this protocol, TBN serves as a convenient N–O source to convert 2-methylquinoline into intermediate nitrile oxides in situ.