Solvent inclusion in the structural voids of form II carbamazepine: single-crystal X-ray diffraction, NMR spectroscopy and Hirshfeld surface analysis†‡,10.1039/B708303N

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Solvent inclusion in the structural voids of form II carbamazepine: single-crystal X-ray diffraction, NMR spectroscopy and Hirshfeld surface analysis†‡

Francesca P. A. Fabbiani,Lindsay T. Byrne,Joshua J. McKinnon,Mark A. Spackman

CrystEngComm Pub Date : 06/25/2007 00:00:00 , DOI:10.1039/B708303N

Abstract

Single-crystal X-ray diffraction and solution ¹H NMR spectroscopy, in conjunction with Hirshfeld surface analysis, give evidence of solvent inclusion in the trigonal polymorph of carbamazepine, which in the unsolvated form is characterised by the presence of large structural voids.

$Graphical abstract: Solvent inclusion in the structural voids of form II carbamazepine: single-crystal X-ray diffraction, NMR spectroscopy and Hirshfeld surface analysis$