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Reduction of aromatic and aliphatic nitro groups to anilines and amines with hypophosphites associated with Pd/C†
Marc Baron,Estelle Métay,Marc Lemaire,Florence Popowycz
Green Chemistry Pub Date : 01/30/2013 00:00:00 , DOI:10.1039/C3GC37024K
Abstract

The reduction of aromatic and aliphatic nitro groups to anilines and amines is performed with good yield and selectivity in short reaction times. A mixture of sodium hypophosphite and phosphinic acid is used in the presence of a heterogeneous catalyst 2.5 mol% of Pd/C (5%) in a biphasic water/2-MeTHF system.

Graphical abstract: Reduction of aromatic and aliphatic nitro groups to anilines and amines with hypophosphites associated with Pd/C
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