Syntheses and anti-HIV activities of (±)-norcarbovir and (±)-norabacavir,10.1039/B700321H

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Syntheses and anti-HIV activities of (±)-norcarbovir and (±)-norabacavir

Weiqiang Huang,Erik De Clercq,Jan Balzarini

Organic & Biomolecular Chemistry Pub Date : 03/01/2007 00:00:00 , DOI:10.1039/B700321H

Abstract

Norcarbovir (1) and norabacavir (2), the desmethylene derivatives of anti-HIV agents carbovir and abacavir, were efficiently synthesized from a common intermediate 4. Their antitumor and antiviral activities were evaluated and the results indicate norabacavir showed comparable anti-HIV activity to that of abacavir.