Synthesis and antibacterial activity of novel neamine derivatives: preponderant role of the substituent position on the neamine core†,10.1039/C2OB07065K

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis and antibacterial activity of novel neamine derivatives: preponderant role of the substituent position on the neamine core†

Nicolas Gernigon,Val\u00e9rie Bordeau,Fabienne Berr\u00e9e,Brice Felden,Bertrand Carboni

Organic & Biomolecular Chemistry Pub Date : 04/25/2012 00:00:00 , DOI:10.1039/C2OB07065K

Abstract

A series of neamine derivatives were prepared from the cyclic carbonate and sulfate of 1,3,2′,6′-tetraazido-3′,4′,-di-O-acetylneamine. Ring opening reactions with diversely substituted amines result in the formation of the corresponding carbamates or sulfonic acids with good overall yields. The antibacterial activities of the synthesized products against E. coli (DH5α) and S. aureus (RN4220) were evaluated. With isolated single regioisomers, the preponderant effect of the 5-positions of the carbamate substituent on the neamine core was demonstrated.